Publications:

- Alghamdi TA, Batchu SN, Hadden MJ, Yerra VG, Liu Y, Bowskill BB, Advani SL, Geldenhuys L, Siddiqi FS, Majumder S, Advani A. Histone H3 serine 10 phosphorylation facilitates endothelial activation in diabetic kidney disease. Diabetes. 2018;67:2668-2681.

- Hadden MJ and Advani A. Histone deacetylase inhibitors and diabetic kidney disease. International Journal of Molecular Sciences. 2018;19:E2630.

- Batchu SN, Thieme K, Zadeh FH, Alghamdi TA, Yerra VG, Hadden MJ, Majumder S, Kabir MG, Bowskill BB, Ladha D, Gramolini AO, Connelly KA, Advani A. The dipeptidyl peptidase 4 substrate CXCL2 has opposing cardiac effects in young mice and aged diabetic mice mediated by Ca2+ flux and phosphoinositide 3-kinase gamma. Diabetes. 2018;67:2443-2455.

- Yerra VG and Advani A. Histones and heart failure in diabetes. Cellular and Molecular Life Sciences. 2018 Epub ahead of print June 22.

- Bugyei-Twum A, Ford C, Civitarese R, Seegobin J, Advani SL, Desjardins JF, Kabir G, Zhang Y, Mitchell M, Switzer J, Thai K, Shen V, Abadeh A, Singh KK, Billia F, Advani A, Gilbert RE, Connelly KA. Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation. Cardiovascular Research. 2018;114:1629-1641.

- Brijmohan AS, Batchu SN, Majumer S, Alghamdi TA, Thieme K, McGaugh S, Liu Y, Advani SL, Bowskill BB, Kabir MG, Geldenhuys L, Siddiqi FS, Advani A. HDAC6 inhibition promotes transcription factor EB activation and is protective in experimental kidney disease. Frontiers in Pharmacology. 2018;34:9.

- Majumder S, Thieme K, Batchu SN, Alghamdi TA, Bowskill BB, Kabir MG, Liu Y, Advani SL, White KE, Geldenhuys L, Tennankore KK, Poyah P, Siddiqi FS, Advani A. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. The Journal of Clinical Investigation. 2018;128:483-499.

- Rajesakaran H, Reich HN, Hladunewich MA, Cattran D, Lovshin JA, Lytvyn Y, Bjornstad P, Lia V, Tse J, Cham L, Majumder S, Bowskill BB, Kabir MG, Gibson IW, Sood MM, Advani A*, Cherney DZI*. Dapagliflozin in focal segmental glomerulosclerosis: a combined human-rodent pilot study. American Journal of Physiology- Renal Physiology. 2018;314:F412-F422.

- Thieme K, Majumder S, Brijmohan AS, Batchu SN, Bowskill BB, Alghamdi TA, Advani SL, Kabir MG, Liu Y, Advani A. EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease. Scientific Reports. 2017;7:3442.

- Alghamdi TA, Majumder S, Thieme K, Batchu SN, White KE, Liu Y, Brijmohan AS, Bowskill BB, Advani SL, Woo M, Advani A. Janus kinase 2 regulates transcription factor EB expression and autophagy completion in glomerular podocytes. Journal of the American Society of Nephrology. 2017;28:2641-2653.

- Lytvyn Y, Har R, Locke A, Lai V, Fong D, Advani A, Perkins BA, Cherney DZ. Renal and vascular effects of uric acid lowering in normouricemic patients with uncomplicated Type 1 diabetes. Diabetes. 2017;66:1939-1949.

- Rajasekeran H, Lytvyn Y, Bozovic A, Lovshin J, Diamandis A, Cattran D, Husain M, Perkins BA, Advani A, Reich HN, Kulasingam V, Cherney DZ. Urinary adenosine excretion in Type 1 diabetes. American Journal of Physiology- Renal Physiology. 2017;313:F184-F191.

- Majumder S and Advani A. VEGF and the diabetic kidney: more than too much of a good thing. Journal of Diabetes and its Complicatons. 2016;31:273-279.

- Markowitz B, Parsons JA, Advani A. Diabetes in emerging adulthood: transitions lost in translation. Canadian Journal of Diabetes. 2016;41:1-5.

- Batchu SN, Brijmohan AS, Advani A. The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease. Clinical Science. 2016;120:987-1003.

- Dos Santos C, Hussain SN, Mathur S, Picard M, Herridge M, Correa J, Bain A, Guo Y, Advani A, Advani SL, Tomlinson G, Katzberg H, Streutker CJ, Cameron JI, Schols A, Gosker H, Batt J; MEND ICU group, the RECOVER program investigators and the Canadian Critical Care Translational Biology Group. Mechanisms of chronic muscle wasting and dysfunction after an intensive care unit stay: a pilot study. American Journal of Respiratory and Critical Care Medicine. 2016;194:821-830.

- Yu CH, Guarna G, Tsao P, Jesuthasan JR, Lau ANC, Siddiq FS, Gilmor JA, Ladha D, Halapy H, Advani A. Incentivizing health care behaviors in emerging adults: a systematic review. Patient Preference and Adherence. 2016;10:371-381.

- Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, Chan L, De Freitas K, Bialik JF, Majumder S, Boo S, Hinz B, Dan Q, Advani A, John R, Wrana JL, Kapus A, Yuen DA. YAP/TAZ are mechanoregulators of TGF-ß-Smad signaling and renal fibrogenesis. Journal of the American Society of Nephrology. 2016;27:3117-3128.

- Batchu SN, Majumder S, Bowskill BB, White KE, Advani SL, Brijmohan AS, Liu Y, Thai K, Azizi PM, Lee WL, Advani A. Prostaglandin I2 receptor agonism preserves beta-cell function and attenuates albuminuria through nephrin-dependent mechanisms. Diabetes. 2016;65:1398-1409.

- Sugiyama M, Gamage A, Zyla R, Armstrong SM, Advani S, Advani A, Wang C, Lee WL. Influenza infection induces platelet-endothelial adhesion which contributes to lung injury. Journal of Virology. 2015;90:1812-1823.

- Siddiqi FS, Majumder S, Thai K, Abdalla M, Hu P, Advani SL, White KE, Bowskill BB, Guarna G, dos Santos CC, Connelly KA, Advani A. The histone methyltransferase enzyme enhancer of zeste homolog 2 protects against podocyte oxidative stress and renal injury in diabetes. Journal of the American Society of Nephrology. 2016;27:2021-2034.

- Majumder S and Advani A. The epigenetic regulation of podocyte function in diabetes. Journal of Diabetes and its Complications. 2015;29:1337-1344.

- Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani SL, Zhang H, Szaszi K, Tabuchi A, Kuebler W, van Slyke P, Dumont DJ, Lee WL. The Tie2-agonist vasculotide rescues mice from lethal influenza infection. Scientific Reports. 2015 Jun 5;5:11030.

- Mahmud FH, De Melo EN, Noordin K, Assor E, Sahota K, Davies-Shaw J, Cutz E, Somers G, Lawson M, Mack DR, Gallego P, McDonald C, Beaton MD, Bax K, Saibil F, Gilbert J, Kirsch S, Perkins BA, Cino M, Szentgyorgyi E, Koltin D, Parikh A, Mukerji G, Advani A, Lou O, Marcon MA. The Celiac Disease and Diabetes-Dietary Intervention and Evaluation Trial (CD-DIET) protocol: a ransomised controlled study to evaluate treatment of asymptomatic coeliac disease in type 1 diabetes. BMJ Open 2015;11:e008097.

- Wang C, Armstrong SM, Sugiyama MG, Tabuchi A, Krauszman A, Kuebler WM, Mullen B, Advani S, Advani A, Lee WL. Influenza primes human lung microvascular endothelium to leak upon exposure to staphylococcus aureus. Am J Respir Cell Mol Biol. 2015;53:459-470.

- Connelly KA, Advani A, Zhang Y, Advani SL, Kabir G, Abadeh A, Desjardins JF, Mitchell M, Thai K, Gilbert RE. Dipeptidyl peptidase-4 inhibition improves cardiac function in experimental myocardial infarction: role of stromal cell-derived factor-1. Journal of Diabetes. 2015 Epub ahead of print Jan 7.

- Siddiqi FS, Chen LH, Advani SL, Thai K, Batchu SN, Alghamdi TA, White KE, Sood MM, Gibson IW, Connelly KA, Marsden PA, Advani A. CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney. Endocrinology. 2015;156:1121-1132.

- Advani A. The end of the road for dual renin angiotensin system blockade in diabetic nephropathy: which way now? Canadian Journal of Diabetes. 2014;38:292-295.

- Connelly KA, Bowskill BB, Advani SL, Thai K, Chen LH, Kabir MG, Gilbert RE, Advani A. Dipeptidyl peptidase-4 inhibition improves left ventricular function in chronic kidney disease. Clinical and Investigative Medicine. 2014;37:E172.

- Connelly KA, Advani A, Advani SL, Zhang Y, Kim YM, Shen V, Thai K, Kelly DJ, Gilbert RE. Impaired cardiac anti-oxidant activity in diabetes: human and correlative experimental studies. Acta Diabetologica. 2014;51:771-782.

- Bugyei-Twum A, Advani A, Advani SL, Zhang Y, Thai K, Kelly DJ, Connelly KA. High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy. Cardiovascular Diabetology. 2014;13:89.

- Canadian Diabetes Association Clinical Practice Guideline Expert Committee, Boyd SR, Advani A, Altomare F, Stockl F. Retinopathy. Canadian Journal of Diabetes. 2014;37 Suppl 1:S137-141.

- Chen LH, Advani SL, Thai K, Kabir MG, Sood MM, Gibson IW, Yuen DA, Connelly KA, Marsden PA, Kelly DJ, Gilbert RE, Advani A. SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease. PLoS One. 2014;9:e92227.

- Kosanam H, Thai K, Zhang Y, Advani A, Connelly KA, Diamandis EP, Gilbert RE. Diabetes induces lysine acetylation of intermediary metabolism enzymes in the kidney. Diabetes. 2014;63:2432-2439.

- Advani A. Vascular endothelial growth factor and the kidney: something of the marvellous. Current Opinion in Nephrology and Hypertension. 2014;23:87-92.

- Patel M, Wang X, Magomedova L, John R, Rasheed A, Santamaria H, Wang W, Tsai R, Qiu L, Orellana A, Advani A, Levi M, Cummins CL. Liver X receptors preserve renal glomerular integrity under normoglycemia and when challenged with diabetes. Diabetologia. 2014;57:435-446.

- Advani A, Connelly KA, Advani SL, Thai K, Zhang Y, Kelly DJ, Gilbert RE. Role of the eNOS-NO system in regulating the anti-proteinuric effects of VEGF receptor 2 inhibition in diabetes. Biomed Research International. 2013;2013: 201475.

- Yuen DA, Connelly KA, Zhang Y, Advani SL, Thai K, Kabir G, Kepecs D, Spring C, Smith C, Batruch I, Kosanam H, Advani A, Diamandis E, Marsden PA, Gilbert RE. Early outgrowth cells release soluble endocrine anti-fibrotic factors that reduce progressive organ fibrosis. Stem Cells. 2013;31:2408-2419.

- Connelly KA, Advani A, Advani SL, Thai K, Thomas S, Krum H, Kelly DJ, Gilbert RE. Combination angiotensin converting enzyme and direct renin inhibition in heart failure following experimental myocardial infarction. Cardiovascular Therapeutics. 2013;31:84-91.

- Siddiqi FS and Advani A. Endothelial-podocyte crosstalk: the missing link between albuminuria and endothelial dysfunction in diabetes. Diabetes. 2013;62:3647-3655.

- Advani A, Buyei-Twum, Connelly KA. Cardiovascular effects of incretins in diabetes. Canadian Journal of Diabetes. 2013;37:309-314.

- Connelly KA, Zhang Y, Advani A, Advani SL, Thai K, Yuen DA, Gilbert RE. DPP-4 inhibition attenuates cardiac dysfunction and adverse remodelling following myocardial infarction in rats with experimental diabetes. Cardiovascular Therapeutics. 2012;31:259-267.

- Yuen DA, Zhang Y, Thai K, Spring C, Chan L, Guo C, Advani A, Sivak J, Gilbert RE. Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by Sirt1 activation. Stem Cells Translational Medicine. 2012;1:921-926.

- Petruziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BN, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice. Journal of Clinical Investigation. 2012;122:759-776.

- Chen L-H, Stead BA, Advani SL, Yaqoob N, Thai K, Kabir MG, Connelly KA, Gilbert RE, Advani A. Hyperglycemia and renal mass ablation synergistically augment albuminuria in the diabetic subtotally nephrectomized rat: implications for modeling diabetic nephropathy. Nephron EXTRA. 2012;2:115-124.

- Zhang Y, Yuen DA, Advani A, Thai K, Advani SL, Kepecs D, Kabir MG, Connelly KA, Gilbert RE. Early outgrowth bone marrow cells attenuate renal injury and dysfunction via an anti-oxidant effect in a mouse model of Type 2 diabetes. Diabetes. 2012:61:2114-2125.

- Advani A and Gilbert RE. The endothelium in diabetic nephropathy. Seminars in Nephrology. 2012;32:199-207.

- Yuen DA, Stead BE, Zhang Y, White KE, Kabir MG, Thai K, Advani SL, Connelly KA, Takano T, Zhu L, Cox AJ, Kelly DJ, Gibson IW, Takahashi T, Harris RC, Advani A. eNOS deficiency predisposes podocytes to injury in diabetes. Journal of the American Society of Nephrology. 2012;23:1810-1823.

- Gilbert RE, Huang Q, Thai K, Advani SL, Lee K, Yuen DA, Connelly KA, Advani A. Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of EGFR. Kidney International. 2011;79:1312-1321.

- Advani A, Huang Q, Thai K, Advani SL, White KE, Kelly DJ, Yuen DA, Connelly KA, Marsden PA, Gilbert RE. Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an eNOS-dependent mechanism. American Journal of Pathology. 2011;178:2205-2214.

- Advani A, Wiggins KJ, Cox AJ, Zhang Y, Gilbert RE, Kelly DJ. Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy. Nephrology. 2011;16:573-581.

- Connelly KA, Advani A, Kim S, Advani SL, Zhang M, White KE, Parker C, Thai K, Krum H, Kelly DJ, Gilbert RE. The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy. Journal of Hypertension. 2011;29:1175-1184.

- Advani A, Connelly KA, Yuen DA, Zhang Y, Advani SL, Trogadis J, Kabir MG, Schachar E, Kuliszewski MA, Leong-Poi H, Stewart DJ, Gilbert RE. Fluorescent microangiography is a novel and widely applicable technique for delineating the renal microvasculature. PLoS One. 2011;6:e24695.

- Yuen DA, Connelly KA, Advani A, Liao C, Kuliszewski MA, Trogadis J, Thai K, Advani SL, Zhang Y, Kelly DJ, Leong-Poi H, Keating A, Marsden PA, Stewart DJ, Gilbert RE. Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease model via a novel antifibrotic mechanism. PLoS One. 2010:e9543.

- Advani A, Johnson SJ, Nicol MR, Papacleovoulou G, Evans DB, Vaikkakara S, Mason JI, Quinton R. Adult-onset hypogonadotropic hypogonadism caused by aberrant expression of aromatase in an adrenocortical adenocarcinoma. 2010. Endocrine Journal;57:651-656 (2010).

- Advani A, Gilbert RE, Thai K, Gow RM, Langham RG, Cox AJ, Connelly AJ, Zhang Y, Herzenberg AM, Christensen PK, Pollock CA, Qi W, Tan SM, Parving HH, Kelly DJ. Expression, localization and pathogenetic mechanisms of the thioredoxin system in diabetic nephropathy. Journal of the American Society of Nephrology. 2009;20:730-741.

- Advani A, Kelly DJ, Cox AJ, White KE, Advani SL, Thai K, Connelly KA, Yuen D, Trogadis J, Herzenberg AM, Kuliszewski MA, Leong-Poi H, Gilbert RE. The (pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase. Hypertension. 2009;54:261-269.

- Nicol MN, Papacleovoulou G, Evans DB, Penning TM, Strachan MW, Advani A, Johnson SJ, Quinton R, Mason JI. Estrogen biosynthesis in H295 adrenocortical tumor cells. Molecular and Cellular Endocrinology. 2009;300:115-120.

- Connelly KA, Kelly DJ, Zhang Y, Prior DL, Advani A, Cox AJ, Thai K, Krum H, Gilbert RE. Inhibition of PKC β by ruboxisaturin preserves cardiac function and reduces extra-cellular matrix production in diabetic cardiomyopathy. Circulation: Heart Failure. 2009;2:129-137.

- Kelly DJ, Edgley AJ, Zhang Y, Thai K, Advani A, Connelly KA, Whiteside CI, Gilbert RE. Protein kinase C-β inhibition attenuates the progression of nephropathy in non-diabetic kidney disease. Nephrology, Dialysis and Transplantation. 2009;24:1782-1790.

- Logan J, Peralta E, Brown K, Moffett M, Advani A, Leech N. Smoothing the transition from paediatric to adult services in Type 1 diabetes. Journal of Diabetes Nursing. 2008;12.

- Advani A, Vaikkakara S, Gill MS, Arun CS, Pearce SH, Ball SG, James RA, Lennard TW, Bliss RD, Quinton R, Johnson SJ. Impact of standardised reporting in adrenocortical carcinoma: a single centre clinicopathological review. Journal of Clinical Pathology. 2008;61:939-944.

- Vaikkakara S, Al-Ozairi E, Lim E-L, Advani A, Ball SG, James RA, Quinton R. The investigation and management of severe hyperandrogenism pre- and post menopause. Gynecological Endocrinology. 2008;24:87-92.

- Advani A, Kelly DJ, Advani SL, Cox AJ, Thai K, Zhang Y, White KE, Gow RM, Marshall SM, Steer BM, Marsden PA, Gilbert RE. Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions. Proc Natl Acad Sci USA. 2007;104:14448-14453.

- Al-Ozairi E, Quinton R, Advani A. Therapeutic response to metformin in an underweight patient with polycystic ovarian syndrome. 2008. Fertility and Sterility 90;1197:e1-4.

- Thomas TH and Advani A. Inflammation in cardiovascular disease and regulation of the actin cytoskeleton in inflammatory cells: the actin cytoskeleton as a target. Cardiovascular and Haematological Agents in Medicinal Chemistry. 2006;4:165-182.

- Advani A and Taylor R. Life-threatening hypokalaemia on a low-carbohydrate diet associated with previously undiagnosed primary hyperaldosteronism. Diabetic Medicine. 2005;22:1605-1607.

- Rawling LD, Advani A, Marshall SM, Thomas TH. Neutrophil antigen exposure is altered with age in relatives of patients with Type 2 diabetes. Diabetologia. 2004;47:353-355.

- Advani A, Marshall SM, Thomas TH. Increasing neutrophil F-actin corrects CD11b exposure in Type 2 diabetes. European Journal of Clinical Investigation. 2004;34:358-364.

- Advani A, Marshall SM, Thomas TH. Impaired neutrophil store-mediated calcium entry in Type 2 diabetes. European Journal of Clinical Investigation. 2004;34:43-49.

- Advani A, Marshall SM, Thomas TH. Impaired neutrophil actin assembly causes persistent CD11b expression and reduced primary granule exocytosis in Type 2 diabetes. Diabetologia. 2002;45:719-727.

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